7.2 Anemia drugs chapter 55 anemia drugs

Question Answer
erythrocytes another name for red blood cells
erythropoieses the process of erythrocyte production
erythropoietin a hormone secreted by the kidneys that increases the rate of production of RBCs in the bone marrow as response to dec oxygen levels in tissues
global the protein part of the hemoglobin molecule
hemtopoiesis the normal formation and development of all blood cell types in the bone marrow
heme part of the hemoglobin molecule; a nonprotein iron containing pigment
hemoglobin (Hgb) a complicit protein iron compound in the blood that carries oxygen to the cells from the lungs and CO2 away from the cells to the lungs
hemolytic anemias anemias resulting from excessive destruction of erythrocytes
hypochromic pertaining to less that normal colour, usually describes a red blood cell with decreased hemoglobin
mucrocytic pertaining to or characterized by mall than normal cells
pernicious anemia a type of megalaoblastic anemia usually seen in older adults and caused by impaired intestinal absorption of vitamin B12 due to lack of availability
reticulocytes immature eruthrocytes characterized by a mesh like pattern of threads and particles at the former site of the nucleus
Spherocytes small, globular, completely hemoglobinated erythrocytes without the usual central concavity or pallor
a deficiency in either _______ or ________ can lead to a hemoglobin deficiency iron and blobin
common causes of iron deficiency blood loss, surgery, childbirth, GI bleeding, menstrual flow and bleeding hemorrhoids
both DNA and protein require vitamin B12 and folic acid B9 to be present in normal amounts for their proper production
both pernicious anemia and folic acid deficiency anemia are types of megaloblastic anemia, because they are both characterized by large, immature RBC''s
Megaloblastic anemia are not usually cause by a lack of intrinsic factor, but are usually related to poor dietary intake – most commonly seen in infancy, childhood, and pregnancy
hemolytic anemias can occur because of abnormalities within the RBCs (intrinsic factors) or as a results of factors outside (extrinsic) to the RBCs
RBC abnormalities caused by intrinsic factor are usually the result of a genetic defect (sickle cell anemia, hereditary spherocytosis, glucose-6-phosphate dehydrogenase (G6PD) deficiency…
iron is essential for the proper function of all biological systems in the body
Deficiency of iron is the principal nutritional deficiency resulting in anemia
dietary sources of iron are meats, certain vegetables and grains, beans, dried fruits, and eggs
iron is an oxygen carrier in both hemoglobin and myoglobin (oxygen carrying molecule in muscle tissue) and is critical for tissue respiration
once in bloodstream iron is used in the bone marrow to make hemoglobin
excess iron is stored as ferritin, primarily in the liver and some in the spleen
contraindications for iron use hemochromatosis (iron overload) hemolytic anemia, and any other anemia not associated with iron deficiency
ADE for oral iron preparations nausea, vomiting, diarrhea, constipation, dark stools, stomach cramps, and stomach pain
absorption of iron can be enhanced when given with ascorbic acid
absorption of iron can be decreased when given with antacids and calcium
iron can decreased the absorption of certain antibiotics
folic acid deficiency usually due to malabsorption syndromes 0 due to it being absorbed by the upper duodenum
ADE from admin of folic acid are rare – can cause yellow discolouration of urine
folic acid supplements can interact with oral contraceptives, corticosteroids, sulphonamides, and dihydrofolate reductase inhibitiros

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